Tspoap1 Gene Summary [Rat]
Predicted to enable benzodiazepine receptor binding activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in cytoplasm. Predicted to be active in calyx of Held; glutamatergic synapse; and mitochondrion. Human ortholog(s) of this gene implicated in dystonia 22, adult-onset and dystonia 22, juvenile-onset. Orthologous to human TSPOAP1 (TSPO associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspoap1 |
| Official Name | TSPO associated protein 1 [Source:RGD Symbol;Acc:708563] |
| Ensembl ID | ENSRNOG00000007957 |
| Bio databases IDs | |
| Aliases | TSPO associated protein 1 |
| Synonyms | BZRAP1, D230016K05, DYT22, KIAA0612, LOC287609, mKIAA0612, PBR-IP, PRAX-1, RBP1, RIM binding protein 1, RIM-BP1, TSPO associated protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tspoap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Nuf2, DHR10-like domain
- Flagellar FliJ protein
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- B-Box C-terminal domain
- ZIP_TSC22D-like
- Fibronectin type 3 domain
- Bin/Amphiphysin/Rvs domain
- Type III secretion protein YscO
- Laminin Domain I
- benzodiazepine receptor binding
- Tropomyosin
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- bZIP
- HOOK protein coiled-coil region
- GDP/GTP exchange factor Sec2p
- SPEC
- prefoldin, beta subunit, archaeal
- Domain of unknown function (DUF4515)
- TPR/MLP1/MLP2-like protein
- Tropomyosin like
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- PLC-beta C terminal
- Ciliary rootlet component, centrosome cohesion
- Src Homology 3 domain superfamily
- voltage-gated calcium channel
- Spectrin repeats
- Domain of unknown function (DUF4201)
- Mechanosensitive ion channel porin domain
- flagellar export protein FliJ
- Apg6 coiled-coil region
- Modifier of rudimentary (Mod(r)) protein
- prefoldin
- Trichohyalin-plectin-homology domain
- FN3
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- basic region leucin zipper
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- dementia
- schizophrenia
- anxiety disorder
- juvenile-onset dystonia type 22
- adult-onset dystonia type 22
- Bardet-Biedl syndrome
- androgenic alopecia
- venous thromboembolism
- preeclampsia
regulates
- neurotransmitter
role in cell
- paired-pulse facilitation
- replication in
- transmission
- plasticity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tspoap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- neuromuscular synaptic transmission
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- protein binding
- benzodiazepine receptor binding