Cadps Gene Summary [Rat]
Enables calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in positive regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in glutamatergic synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human CADPS (calcium dependent secretion activator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cadps |
| Official Name | calcium dependent secretion activator [Source:RGD Symbol;Acc:708573] |
| Ensembl ID | ENSRNOG00000008570 |
| Bio databases IDs | |
| Aliases | calcium dependent secretion activator |
| Synonyms | AU067781, Ca2+ dependent activator for secretion, Ca2+-dependent secretion activator, CADPS1, calcium dependent secretion activator, CAPS, CAPS1, Caps2, LOC103690082, mKIAA1121, UNC-31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cadps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- calcium ion binding
- protein binding
- Pleckstrin homology-like domain
- MUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- metabolic syndrome X
- schizophrenia
- cancer
- high hyperdiploid acute lymphoblastic leukemia
- pervasive developmental disorder
- advanced cancer
- strabismus
- respiratory failure
- colorectal carcinoma
role in cell
- expression in
- phosphorylation in
- quantity
- fusion
- cell death
- migration
- organization
- priming
- function
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- soluble fraction
- vesicle membrane fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell periphery
- perinuclear region
- cellular membrane
- cytosol
- synaptosomes
- dense-core vesicles
- cytoplasmic vesicles
- secretory vesicles
- secretory granules
- detergent-soluble fraction
- synaptic vesicle fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cadps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- synaptic vesicle exocytosis
- exocytosis
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- metal ion binding
- lipid binding