Cdh2

Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of Rho protein signal transduction; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cdh2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh2 gene, providing context for its role in the cell.