Colec10 Gene Summary [Rat]
Predicted to enable D-mannose binding activity and chemoattractant activity. Predicted to be involved in several processes, including complement activation, lectin pathway; cranial skeletal system development; and positive regulation of opsonization. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 3. Orthologous to human COLEC10 (collectin subfamily member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Colec10 |
| Official Name | collectin subfamily member 10 [Source:RGD Symbol;Acc:1307149] |
| Ensembl ID | ENSRNOG00000008591 |
| Bio databases IDs | |
| Aliases | collectin subfamily member 10 |
| Synonyms | 3MC3, CL-10, CL-34, CL-L1, COLLECTIN 34, collectin sub-family member 10, LOC239447 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Colec10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- chemoattractant
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- protein binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- idiopathic pulmonary fibrosis
- psoriasis
- bone disorder
- 3MC syndrome type 3
- insulin-dependent diabetes mellitus
- epithelial basal cell carcinoma
- microscopic hematuria
role in cell
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Colec10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- positive chemotaxis
- complement activation, lectin pathway
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- collagen
- external side of plasma membrane
- Golgi apparatus
- multivesicular body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannose binding
- chemoattractant activity