Colec11 Gene Summary [Rat]
Predicted to enable several functions, including calcium-dependent carbohydrate binding activity; identical protein binding activity; and monosaccharide binding activity. Predicted to be involved in defense response to symbiont; positive regulation of opsonization; and proteolysis. Predicted to be located in extracellular space. Predicted to be part of collagen trimer and ribonucleoprotein complex. Human ortholog(s) of this gene implicated in 3MC syndrome 2. Orthologous to human COLEC11 (collectin subfamily member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Colec11 |
| Official Name | collectin sub-family member 11 [Source:RGD Symbol;Acc:1309678] |
| Ensembl ID | ENSRNOG00000008373 |
| Bio databases IDs | |
| Aliases | collectin sub-family member 11 |
| Synonyms | 3MC2, CL-11, CL-K1, CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, Collectin-11, collectin sub-family member 11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Colec11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- calcium ion binding
- Collagen triple helix repeat (20 copies)
- fucose binding
- protein binding
- carbohydrate binding
- identical protein binding
- mannose binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hereditary disorder
- liver cancer
- 3MC syndrome type 2
- reperfusion injury
- acute myeloid leukemia
- hepatitis B virus-related hepatocellular carcinoma
- 3MC syndrome
regulates
- blood urea nitrogen
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Colec11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- complement activation
- complement activation, lectin pathway
- proteolysis
- antimicrobial humoral response
- developmental process
- execution phase of apoptosis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- collagen
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- DNA binding
- identical protein binding
- mannose binding
- protein binding
- fucose binding
- calcium ion binding