COLEC10 Gene Summary [Human]
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | COLEC10 |
| Official Name | collectin subfamily member 10 [Source:HGNC Symbol;Acc:HGNC:2220] |
| Ensembl ID | ENSG00000184374 |
| Bio databases IDs | |
| Aliases | collectin subfamily member 10 |
| Synonyms | 3MC3, CL-10, CL-34, CL-L1, COLLECTIN 34, collectin sub-family member 10, LOC239447 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COLEC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- chemoattractant
- Lectin C-type domain
- Collagen triple helix repeat (20 copies)
- protein binding
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- idiopathic pulmonary fibrosis
- psoriasis
- bone disorder
- 3MC syndrome type 3
- insulin-dependent diabetes mellitus
- epithelial basal cell carcinoma
- microscopic hematuria
role in cell
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COLEC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface pattern recognition receptor signaling pathway
- positive chemotaxis
- complement activation, lectin pathway
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- collagen
- external side of plasma membrane
- Golgi apparatus
- multivesicular body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannose binding
- chemoattractant activity