Sdr16c5 Gene Summary [Rat]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; all-trans-retinol dehydrogenase (NAD+) activity; and transcription corepressor activity. Predicted to be involved in keratinocyte proliferation; negative regulation of macromolecule biosynthetic process; and retinoid metabolic process. Predicted to be located in several cellular components, including chromatin; endoplasmic reticulum membrane; and nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in lipid droplet. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdr16c5 |
| Official Name | short chain dehydrogenase/reductase family 16C, member 5 [Source:RGD Symbol;Acc:1565999] |
| Ensembl ID | ENSRNOG00000008871 |
| Bio databases IDs | |
| Aliases | short chain dehydrogenase/reductase family 16C, member 5 |
| Synonyms | EPHD-2, RDH#2, RDH-E2, retSDR2, RGD1565999, short chain dehydrogenase/reductase family 16C member 5, short chain dehydrogenase/reductase family 16C, member 5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sdr16c5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyketide synthase keto reductase domain
- Rossmann-fold NAD(P)(+)-binding proteins
- transcription co-repressor
- retinol dehydrogenase
- KR domain
- transcription factor binding
- enzyme
- protein binding
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Sdr16c5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- breast carcinoma
- cervical squamous cell carcinoma and endocervical adenocarcinoma
- epithelial uterine cancer
- cervical cancer
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- proliferation
- expression in
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sdr16c5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression, epigenetic
- keratinocyte proliferation
- retinol metabolic process
- retinal metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- nucleus
- transcriptional repressor complex
- endoplasmic reticulum
- chromatin
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- retinol dehydrogenase activity
- transcription corepressor activity