Slc35a1 Gene Summary [Rat]
Predicted to enable CMP-N-acetylneuraminate transmembrane transporter activity and antiporter activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process; CMP-N-acetylneuraminate transmembrane transport; and N-acetylneuraminate metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIf. Orthologous to human SLC35A1 (solute carrier family 35 member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc35a1 |
| Official Name | solute carrier family 35 member A1 [Source:RGD Symbol;Acc:1311359] |
| Ensembl ID | ENSRNOG00000008908 |
| Bio databases IDs | |
| Aliases | solute carrier family 35 member A1 |
| Synonyms | CDG2F, CMP-SA-Tr, CMP-Sia-Tr, CMPST, CST, hCST, Slc35a1 predicted, solute carrier family 35 (CMP-sialic acid transporter), member 1, solute carrier family 35 member A1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc35a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide-sugar transporter
- EamA-like transporter family
- antiporter
- protein binding
- CMP-sialic acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- congenital disorder of glycosylation type 2f
- progressive familial intrahepatic cholestasis type 1
- infection by Enterovirus D68
regulates
- UMP
- UDP-D-galactose
- CMP-sialic acid
- AMP
- UDP-N-acetyl-D-galactosamine
- carbohydrate
- cytidine 3'-phosphate
- N-acetylneuraminic acid
role in cell
- production in
- viral entry in
- sialylation in
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc35a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- carbohydrate metabolic process
- CMP-N-acetylneuraminate transport
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- CMP-N-acetylneuraminate transmembrane transporter activity