Fxyd3 Gene Summary [Rat]

This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Details

Type
Protein Coding
Official Symbol
Fxyd3
Official Name
FXYD domain-containing ion transport regulator 3 [Source:RGD Symbol;Acc:620825]
Ensembl ID
ENSRNOG00000021095
Bio databases IDs NCBI: 116831 Ensembl: ENSRNOG00000021095
Aliases FXYD domain-containing ion transport regulator 3
Synonyms FXYD domain-containing ion transport regulator 3, ION TRANSPORT REGULATOR p11, MAT8, PLML
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fxyd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ATPase binding
  • ATP1G1/PLM/MAT8 family
  • chloride channel
  • protein binding
  • phenylalanine-X-tyrosine-aspartate (FXYD) family
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-small cell lung cancer
  • non-small cell lung carcinoma
  • endometrioma
  • multiple system atrophy
regulated by
regulates
  • chloride

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • cellular membrane
  • endoplasmic reticulum membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Fxyd3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • sodium ion transport
  • regulation of sodium ion transmembrane transporter activity
  • regulation of ion transport
  • chloride transport

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • extracellular vesicular exosome
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • sodium channel regulator activity
  • chloride channel activity
  • ATPase binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.