Nans Gene Summary [Rat]
Predicted to enable N-acylneuraminate-9-phosphate synthase activity. Predicted to be involved in CMP-N-acetylneuraminate biosynthetic process; N-acetylneuraminate biosynthetic process; and glycosylation. Is active in cytosol. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Genevieve-type. Orthologous to human NANS (N-acetylneuraminate synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nans |
| Official Name | N-acetylneuraminate synthase [Source:RGD Symbol;Acc:1311943] |
| Ensembl ID | ENSRNOG00000008945 |
| Bio databases IDs | |
| Aliases | N-acetylneuraminate synthase |
| Synonyms | 4632418E04Rik, BB056474, HEL-S-100, N-acetylneuraminate synthase, N-acetylneuraminic acid synthase (sialic acid synthase), SAS, SEMDCG, SEMDG, Sialic Acid Synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nans often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAF domain
- Domains similar to fish antifreeze type III protein
- This domain family includes a range of different proteins
- N-acylneuraminate-9-phosphate synthase
- DAHP synthetase I family
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Genevieve type spondyloepimetaphyseal dysplasia
- preeclampsia
- breast cancer
- infection by Enterovirus D68
regulates
- N-acetylneuraminic acid
- 3-deoxyglycero-galacto-nonulosonic acid
- NANS
- Myelin
- CMP-sialic acid
role in cell
- phagocytosis by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nans gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- carbohydrate biosynthetic process
- CMP-N-acetylneuraminate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- N-acylneuraminate-9-phosphate synthase activity
- N-acylneuraminate cytidylyltransferase activity
- N-acetylneuraminate synthase activity