Fbxo32 Gene Summary [Rat]
Predicted to enable ubiquitin-protein transferase activity. Involved in muscle atrophy; positive regulation of cardiac muscle cell apoptotic process; and regulation of muscle adaptation. Predicted to be located in Z disc; cytosol; and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Used to study muscular atrophy. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo32 |
| Official Name | F-box protein 32 [Source:RGD Symbol;Acc:620373] |
| Ensembl ID | ENSRNOG00000006738 |
| Bio databases IDs | |
| Aliases | F-box protein 32 |
| Synonyms | 4833442G10Rik, AI430017, AK014612, ATROGIN1, F-box protein 32, Fbx32, Gm20361, LOC100504698, MAFbx |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- ubiquitin-protein transferase activity
- nuclear localization sequence
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Fbxo32 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- atrial fibrillation
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- preeclampsia
- Duchenne muscular dystrophy
- pancreatic neoplasia
- organismal death
- abdominal aortic aneurysm
role in cell
- expression in
- migration
- invasion by
- growth
- signaling in
- apoptosis
- degradation in
- survival
- differentiation
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to denervation involved in regulation of muscle adaptation
- cellular response to dexamethasone stimulus
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding