Sln Gene Summary [Rat]
Predicted to enable enzyme regulator activity. Predicted to be involved in several processes, including negative regulation of ATPase-coupled calcium transmembrane transporter activity; positive regulation of cold-induced thermogenesis; and sarcoplasmic reticulum calcium ion transport. Predicted to be located in sarcoplasmic reticulum membrane. Orthologous to human SLN (sarcolipin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sln |
| Official Name | sarcolipin [Source:RGD Symbol;Acc:1305224] |
| Ensembl ID | ENSRNOG00000009047 |
| Bio databases IDs | |
| Aliases | sarcolipin |
| Synonyms | 2310045A07Rik, sarcolipin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- Sarcolipin
- carboxy-terminal luminal tail domain
- phospholamban, sarcolipin, and sarcolamban family of bioactive peptides
- enzyme inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- oral submucous fibrosis
- hypothermia
- obesity
- androgenic alopecia
- preeclampsia
- epileptic seizure
- X-linked bulbospinal atrophy
role in cell
- number
- size
- relaxation
- generation
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- sarcoplasmic reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of catalytic activity
- sarcoplasmic reticulum calcium ion transport
- negative regulation of protein complex disassembly
- calcium ion transport
- regulation of calcium ion transport
- negative regulation of calcium ion import
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme inhibitor activity
- ATPase binding