Atp2a2 Gene Summary [Rat]
Enables several functions, including ATP binding activity; P-type calcium transporter activity; and lutropin-choriogonadotropic hormone receptor binding activity. Involved in several processes, including calcium ion transport; regulation of cardiac muscle cell membrane potential; and regulation of cardiac muscle contraction. Located in several cellular components, including apical ectoplasmic specialization; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Used to study abdominal obesity-metabolic syndrome 1; congestive heart failure; and type 2 diabetes mellitus. Biomarker of euthyroid sick syndrome; heart disease; hypothyroidism; pulmonary hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2a2 |
| Official Name | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [Source:RGD Symbol;Acc:2174] |
| Ensembl ID | ENSRNOG00000001285 |
| Bio databases IDs | |
| Aliases | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
| Synonyms | 9530097L16RIK, ATP2B, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2, Ca-transporting atpase sarcoplasmic reticulum type, D5Wsu150e, DAR, DD, mKIAA4195, Sarcoplasmic reticulum ca2+ atpase, SERCA2, Serca2a/b, SercaII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- magnesium-translocating P-type ATPase
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- G-protein-coupled receptor binding
- ATP binding
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- ion channel binding
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- Ca2+-transporting ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- enzyme binding
- calcium ion binding
- protein binding
- L4 loop domain
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- calcium channel regulator
- RNA binding
- K+-transporting ATPase, B subunit
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- neoplasia
- bipolar I disorder
- major depression
- schizophrenia
- epithelial cancer
- cachexia
- persistent atrial fibrillation
role in cell
- proliferation
- expression in
- phosphorylation in
- depolarization
- cell death
- production in
- binding in
- homeostasis
- differentiation
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- caveolae fraction
- detergent-soluble membrane fractions
- membrane fraction
- longitudinal sarcoplasmic reticulum fraction
- perinuclear region
- cellular membrane
- Plasma Membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- myofilaments
- intercellular junctions
- sarcomere
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- microsome
- nuclear envelope
- synaptic vesicles
- sarcoplasmic reticulum vesicle
- Z line
- transverse tubules
- microsomal membrane
- cellular protrusions
- ribbon synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- regulation of cardiac muscle cell membrane potential
- transition between fast and slow fiber
- elevation of endoplasmic reticulum calcium ion concentration
- epidermis development
- cell adhesion
- ER-nucleus signaling pathway
- negative regulation of heart contraction
- autophagic vacuole assembly
- calcium ion transmembrane transport
- endoplasmic reticulum calcium ion homeostasis
- cardiac muscle hypertrophy in response to stress
- T-tubule organization
- ion transmembrane transport
- negative regulation of receptor binding
- cellular calcium ion homeostasis
- regulation of the force of heart contraction
- neuron homeostasis
- sarcoplasmic reticulum calcium ion transport
- autophagic vacuole docking
- positive regulation of cardiac muscle cell apoptotic process
- cellular response to oxidative stress
- regulation of cardiac muscle contraction by calcium ion signaling
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- sarcoplasmic reticulum
- platelet dense tubular network membrane
- membrane
- endoplasmic reticulum
- plasma membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
- calcium ion binding
- calcium-transporting ATPase activity
- ion channel binding
- S100 protein binding
- enzyme binding