Ppargc1a Gene Summary [Rat]
Enables several functions, including alpha-tubulin binding activity; nuclear estrogen receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; regulation of primary metabolic process; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); sciatic neuropathy; and steatotic liver disease (multiple). Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); liver disease (multiple); placental insufficiency; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppargc1a |
| Official Name | PPARG coactivator 1 alpha [Source:RGD Symbol;Acc:620925] |
| Ensembl ID | ENSRNOG00000004473 |
| Bio databases IDs | |
| Aliases | PPARG coactivator 1 alpha |
| Synonyms | A830037N07RIK, Gm11133, LEM6, LRPGC1, peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, peroxisome proliferative activated receptor, γ, coactivator 1 α, Peroxisome Proliferator-Activating Receptor Gamma Coactivator 1 Alpha, Peroxisome Proliferator-Activating Receptor γ Coactivator 1alpha, Peroxisome Proliferator-Activating Receptor γ Coactivator 1 α, PGC-1, PGC1A, PGC-1alpha, PGC-1(alpha), Pgc-1alpha-a, PGC-1v, PGC-1α, PGC-1(α), Pgco1, PGCvf, PGCvf-1, PPARGC1, PPARGC-1-alpha, PPARGC-1-α, PPARG coactivator 1 alpha, PPARG coactivator 1 α, ppar γ coactivator 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppargc1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arginine serine dipeptide repeat domain
- transcription regulator
- LXXLL motif
- transcription co-activator
- RNA recognition motif
- transcription cofactor
- transcription factor binding
- leucine zipper domain
- chromatin binding
- estrogen receptor binding
- receptor binding domain
- peroxisome proliferator activated receptor binding
- alpha-tubulin binding
- Complexin_NTD
- MEF2 binding domain
- ubiquitin protein ligase binding
- RNA recognition motif (RRM) superfamily
- activation domain
- nuclear receptor domain
- ligand-dependent nuclear receptor interactor
- transcription factor binding domain
- nuclear localization sequence
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- SR domain
- RNA-binding domain
Pathways
Biological processes and signaling networks where the Ppargc1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Apelin Adipocyte Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Estrogen Receptor Signaling
- FXR/RXR Activation
- LPS/IL-1 Mediated Inhibition of RXR Function
- Mitochondrial Dysfunction
- Osteoarthritis Pathway
- PPAR Signaling
- PPARα/RXRα Activation
- PXR/RXR Activation
- RAR Activation
- Serotonin Receptor Signaling
- Sirtuin Signaling Pathway
- TR/RXR Activation
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- adenoma formation
- neurodegeneration
- Huntington disease
- thrombocytopenia
- colorectal cancer
- kidney carcinoma
- renal cancer
- prostate cancer
role in cell
- expression in
- growth
- accumulation in
- cell viability
- quantity
- apoptosis
- phosphorylation in
- activation in
- cell death
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- ribosome
- Mitochondria
- sarcomere
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
- chromatin
- perikaryon
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppargc1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- respiratory electron transport chain
- response to starvation
- response to dietary excess
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of circadian rhythm
- transcription initiation from RNA polymerase II promoter
- positive regulation of gluconeogenesis
- negative regulation of neuron apoptotic process
- brown fat cell differentiation
- circadian regulation of gene expression
- positive regulation of fatty acid oxidation
- positive regulation of transcription, DNA-dependent
- negative regulation of smooth muscle cell proliferation
- energy homeostasis
- neuron apoptotic process
- gluconeogenesis
- response to muscle activity
- macromolecular complex assembly
- digestion
- regulation of transcription, DNA-dependent
- cellular respiration
- mRNA processing
- mitochondrion organization
- adipose tissue development
- cellular glucose homeostasis
- fatty acid oxidation
- positive regulation of gene expression
- temperature homeostasis
- cellular response to oxidative stress
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- DNA binding
- ligand-dependent nuclear receptor binding
- transcription cofactor activity
- protein binding
- ubiquitin protein ligase binding
- RNA binding
- transcription coactivator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- sequence-specific DNA binding
- transcription factor binding