Amn Gene Summary [Rat]
Predicted to enable cargo receptor activity and signaling receptor binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane protein transport; cobalamin metabolic process; and cobalamin transport. Predicted to act upstream of or within renal protein absorption. Located in brush border membrane and endocytic vesicle. Part of protein-containing complex. Human ortholog(s) of this gene implicated in megaloblastic anemia. Orthologous to human AMN (amnion associated transmembrane protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amn |
| Official Name | amnion associated transmembrane protein [Source:RGD Symbol;Acc:1308634] |
| Ensembl ID | ENSRNOG00000009050 |
| Bio databases IDs | |
| Aliases | amnion associated transmembrane protein |
| Synonyms | amnion associated transmembrane protein, amnionless, IGS2, PRO1028 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Amn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- protein binding
- receptor binding
- Amnionless
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Imerslund-Grasbeck syndrome type 2
- enterocyte cobalamin malabsorption
- non-insulin-dependent diabetes mellitus
- proteinuria
- suicidal ideation
- Imerslund-Grasbeck syndrome type 1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- Extracellular Space
- apical compartment
- cellular membrane
- apical cell surfaces
- apical membrane
- endocytotic vesicle
- brush border
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Amn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal protein absorption
- protein localization
- Golgi to plasma membrane protein transport
- cobalamin metabolic process
- cobalamin transport
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- endocytic vesicle
- extracellular space
- extracellular vesicular exosome
- brush border membrane
- coated pit
- membrane
- endosome membrane
- receptor complex
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity
- receptor binding