Stambp Gene Summary [Rat]
Predicted to enable K63-linked deubiquitinase activity and protein domain specific binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within mitotic cytokinesis; negative regulation of hippocampal neuron apoptotic process; and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cleavage furrow and endosome. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stambp |
| Official Name | Stam binding protein [Source:RGD Symbol;Acc:619963] |
| Ensembl ID | ENSRNOG00000012227 |
| Bio databases IDs | |
| Aliases | Stam binding protein |
| Synonyms | 5330424L14Rik, 5730422L11Rik, AMSH, LOC100507148, MICCAP, mKIAA4198, STAM binding protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stambp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- Mpr1p, Pad1p N-terminal (MPN) domains
- JAB1 subdomain homology domain
- RXXK motif
- nuclear localization sequence
- protein domain specific binding
- enzyme
- PXXP motif
- protein binding
- USP8 dimerization domain
- Sh3 domain binding motif
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microcephaly-capillary malformation syndrome
- ptosis
- uterine leiomyoma
- leiomyomatosis
- growth failure
- organismal death
- disorder of pregnancy
role in cell
- phosphorylation in
- proliferation
- cell death
- survival
- ubiquitination in
- apoptosis
- cytostasis
- deubiquitination in
- degeneration
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- nucleoplasm
- cleavage furrow
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stambp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- negative regulation of Ras protein signal transduction
- cytokinesis after mitosis
- positive regulation of cell proliferation
- proteolysis
- JAK-STAT cascade
- protein K63-linked deubiquitination
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- extracellular vesicular exosome
- endosome
- cleavage furrow
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- metal ion binding