Sox17 Gene Summary [Rat]
Enables sequence-specific double-stranded DNA binding activity. Involved in response to alkaloid. Located in nucleus. Biomarker of cholangiocarcinoma and pulmonary hypertension. Human ortholog(s) of this gene implicated in intracranial aneurysm; patent ductus arteriosus; and vesicoureteral reflux. Orthologous to human SOX17 (SRY-box transcription factor 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox17 |
| Official Name | SRY-box transcription factor 17 [Source:RGD Symbol;Acc:1305371] |
| Ensembl ID | ENSRNOG00000027357 |
| Bio databases IDs | |
| Aliases | SRY-box transcription factor 17 |
| Synonyms | SRY-box transcription factor 17, SRY (sex determining region Y)-box 17, VUR3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sox17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-catenin binding domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- beta-catenin binding
- high mobility group (HMG)-box domain superfamily
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- Sox 17/18 central domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sox17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- tumorigenesis
- cholestasis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- acute cholecystitis
- epithelial uterine cancer
- colorectal carcinomagenesis
- lung adenocarcinoma
role in cell
- expression in
- binding in
- proliferation
- growth
- integrity
- differentiation
- migration
- apoptosis
- cell division
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sox17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac cell fate specification
- endodermal digestive tract morphogenesis
- gall bladder development
- endodermal cell fate determination
- signal transduction involved in regulation of gene expression
- regulation of stem cell proliferation
- outflow tract morphogenesis
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- embryonic foregut morphogenesis
- positive regulation of stem cell differentiation
- heart development
- positive regulation of transcription, DNA-dependent
- angiogenesis
- negative regulation of cell growth
- ureter development
- heart looping
- Wnt receptor signaling pathway
- regulation of stem cell division
- endoderm formation
- inner cell mass cellular morphogenesis
- spermatogenesis
- rostrocaudal neural tube patterning
- common bile duct development
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- stem cell fate specification
- positive regulation of protein catabolic process
- endocardial cell differentiation
- cardiogenic plate morphogenesis
- embryonic heart tube morphogenesis
- embryonic heart tube development
- cardiac cell fate determination
- endocardium formation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- protein destabilization
- heart formation
- metanephros development
- cell migration involved in gastrulation
- positive regulation of gene expression
- endodermal cell fate specification
- gene expression
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity