Pdxp Gene Summary [Rat]
Enables growth factor binding activity. Predicted to be involved in several processes, including positive regulation of actin filament depolymerization; pyridoxal phosphate catabolic process; and regulation of cell cycle process. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Predicted to be located in several cellular components, including cleavage furrow; midbody; and ruffle membrane. Predicted to be active in cytosol; glutamatergic synapse; and postsynapse. Orthologous to human PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdxp |
| Official Name | pyridoxal phosphatase [Source:RGD Symbol;Acc:1586212] |
| Ensembl ID | ENSRNOG00000009570 |
| Bio databases IDs | |
| Aliases | pyridoxal phosphatase |
| Synonyms | 1600027H05Rik, Chronophin, CIN, dJ37E16.5, PLP, PLPP, PYRIDOXAL PHOSPHATASE, pyridoxal (pyridoxine, vitamin B6) phosphatase, Rbp1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdxp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycolate/pyridoxal phosphate phosphatase family
- heat shock protein binding
- HAD-superfamily class IIA hydrolase, TIGR01459
- protein binding
- magnesium ion binding
- HAD-superfamily subfamily IIA hydrolase, TIGR01457
- Haloacid Dehalogenase Superfamily Class (subfamily) IIA
- HAD-hyrolase-like
- protein phosphatase
- phosphatase
- protein homodimerization
- HAD-superfamily subfamily IIA hydrolase, TIGR01458
- Haloacid Dehalogenase-like Hydrolases
- growth factor binding
- haloacid dehalogenase-like hydrolase
Pathways
Biological processes and signaling networks where the Pdxp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle weakness
regulates
- cofilin
- F Actin
- pyridoxal phosphate
- amino acids
- vitamin
- Adf
role in cell
- formation
- mitosis
- cell cycle progression
- organization
- cytokinesis
- depolymerization
- response by
- formation in
- multinucleation
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- actin cytoskeleton
- contractile rings
- midbody
- intercellular junctions
- cytosol
- membrane ruffles
- spindle pole
- cleavage furrow
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdxp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitosis
- positive regulation of actin filament depolymerization
- pyridoxal phosphate catabolic process
- protein dephosphorylation
- regulation of cytokinesis
- dephosphorylation
- cellular response to ATP
- actin rod assembly
Cellular Component
Where in the cell the gene product is active
- contractile ring
- cell-cell junction
- cleavage furrow
- cytoplasm
- actin cytoskeleton
- cytosol
- ruffle membrane
- midbody
- plasma membrane
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- phosphoprotein phosphatase activity
- heat shock protein binding
- protein binding
- protein homodimerization activity
- pyridoxal phosphatase activity
- myosin phosphatase activity