PDXP Gene Summary [Human]
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDXP |
| Official Name | pyridoxal phosphatase [Source:HGNC Symbol;Acc:HGNC:30259] |
| Ensembl ID | ENSG00000241360 |
| Bio databases IDs | |
| Aliases | pyridoxal phosphatase, chronophin |
| Synonyms | 1600027H05Rik, Chronophin, CIN, dJ37E16.5, PLP, PLPP, PYRIDOXAL PHOSPHATASE, pyridoxal (pyridoxine, vitamin B6) phosphatase, Rbp1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDXP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycolate/pyridoxal phosphate phosphatase family
- heat shock protein binding
- HAD-superfamily class IIA hydrolase, TIGR01459
- protein binding
- magnesium ion binding
- HAD-superfamily subfamily IIA hydrolase, TIGR01457
- Haloacid Dehalogenase Superfamily Class (subfamily) IIA
- HAD-hyrolase-like
- protein phosphatase
- phosphatase
- protein homodimerization
- HAD-superfamily subfamily IIA hydrolase, TIGR01458
- Haloacid Dehalogenase-like Hydrolases
- growth factor binding
- haloacid dehalogenase-like hydrolase
Pathways
Biological processes and signaling networks where the PDXP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle weakness
regulates
- cofilin
- F Actin
- pyridoxal phosphate
- amino acids
- vitamin
- Adf
role in cell
- formation
- mitosis
- cell cycle progression
- organization
- cytokinesis
- depolymerization
- response by
- formation in
- multinucleation
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- actin cytoskeleton
- contractile rings
- midbody
- intercellular junctions
- cytosol
- membrane ruffles
- spindle pole
- cleavage furrow
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDXP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitosis
- positive regulation of actin filament depolymerization
- pyridoxal phosphate catabolic process
- protein dephosphorylation
- regulation of cytokinesis
- dephosphorylation
- cellular response to ATP
- actin rod assembly
Cellular Component
Where in the cell the gene product is active
- contractile ring
- cell-cell junction
- cleavage furrow
- cytoplasm
- actin cytoskeleton
- cytosol
- ruffle membrane
- midbody
- plasma membrane
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- phosphoprotein phosphatase activity
- heat shock protein binding
- protein binding
- protein homodimerization activity
- pyridoxal phosphatase activity
- myosin phosphatase activity