Cyb5r4 Gene Summary [Rat]
Enables NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding activity; and heme binding activity. Involved in NADP metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb5r4 |
| Official Name | cytochrome b5 reductase 4 [Source:RGD Symbol;Acc:621834] |
| Ensembl ID | ENSRNOG00000010024 |
| Bio databases IDs | |
| Aliases | cytochrome b5 reductase 4 |
| Synonyms | B5+B5R, cb5/cb5R, cytochrome b5 reductase 4, dJ676J13.1, NCB5OR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyb5r4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- CS domain
- flavin adenine dinucleotide binding
- NADH or NADPH:heme protein oxidoreductase
- cytochrome-b5 reductase
- enzyme
- heme binding
- Oxidoreductase FAD-binding domain
- alpha-crystallin Hsps/p23-like
- NADPH oxidase
- Cytochrome b5-like Heme/Steroid binding domain
- Oxidoreductase NAD-binding domain
- NADPH-ferrihemoprotein reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyb5r4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- superoxide metabolic process
- insulin secretion
- glucose homeostasis
- response to antibiotic
- detection of oxygen
- cell development
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- cytoplasm
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- cytochrome-b5 reductase activity
- metal ion binding
- NAD(P)H oxidase activity
- oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
- heme binding