Ap3d1 Gene Summary [Rat]
Involved in synaptic vesicle budding from endosome. Predicted to be located in axon. Predicted to be part of AP-3 adaptor complex. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and terminal bouton. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap3d1 |
| Official Name | adaptor related protein complex 3 subunit delta 1 [Source:RGD Symbol;Acc:1308659] |
| Ensembl ID | ENSRNOG00000018977 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 3 subunit delta 1 |
| Synonyms | adaptor-related protein complex 3, delta 1 subunit, adaptor related protein complex 3 subunit delta 1, adaptor related protein complex 3 subunit δ 1, adaptor-related protein complex 3, δ 1 subunit, ADTD, AP3D, AP3D1 isoform 1, Ap3 δ, Bolvr, delta ADAPTIN, hBLVR, HPS10, mBLVR1, mh, mocha, δ ADAPTIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap3d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- non-SMC mitotic condensation complex subunit 1
- AP-3 complex subunit delta-1
- protein binding
- Adaptin N terminal region
Pathways
Biological processes and signaling networks where the Ap3d1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- epithelial cancer
- Hermansky-Pudlak syndrome
- Hermansky-Pudlak syndrome 10
- myocardial infarction
- idiopathic scoliosis
- generalized epilepsy
- kidney carcinoma
role in cell
- differentiation
- activation
- size
- organization
- production
- function in
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- endosomes
- Golgi Apparatus
- trans Golgi network
- endosomal membrane
- dendritic spines
- neurites
- nerve ending
- synaptosomes
- perikaryon
- axons
- axon terminals
- mossy fibers
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap3d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- anterograde axon cargo transport
- intracellular transport
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib
- positive regulation of transcription from RNA polymerase II promoter
- intracellular protein transport
- protein targeting to vacuole
- Golgi to vacuole transport
- melanosome organization
- vesicle-mediated transport
- synaptic vesicle budding from endosome
- synaptic vesicle coating
- synaptic vesicle membrane organization
- protein localization in membrane
- endosome to melanosome transport
- cargo loading into clathrin-coated vesicle, AP-3-mediated
- positive regulation of NK T cell differentiation
- anterograde synaptic vesicle transport
Cellular Component
Where in the cell the gene product is active
- early endosome
- terminal button
- membrane
- AP-3 adaptor complex
- Golgi membrane
- endosome membrane
- Golgi apparatus
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding