Ube2g1 Gene Summary [Rat]
Enables ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Orthologous to human UBE2G1 (ubiquitin conjugating enzyme E2 G1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2g1 |
| Official Name | ubiquitin-conjugating enzyme E2G 1 [Source:RGD Symbol;Acc:620392] |
| Ensembl ID | ENSRNOG00000010041 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2G 1 |
| Synonyms | 2700059C12Rik, AI256795, AU014992, D130023C12RIK, E217K, UBC7, UBE2G, ubiquitin-conjugating enzyme E2G 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2g1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2g1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- non-insulin-dependent diabetes mellitus
- major depression
regulates
- PRKN
- DIO2
- SR4835
role in cell
- CSN5i-3 sensitivity
- CSN5i-3 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2g1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein polyubiquitination
- protein K63-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding