Rgs4 Gene Summary [Rat]
Enables G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs4 |
| Official Name | regulator of G-protein signaling 4 [Source:RGD Symbol;Acc:3567] |
| Ensembl ID | ENSRNOG00000002773 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 4 |
| Synonyms | ESTM48, ESTM50, GRS4, regulator of G-protein signaling 4, RGP4, SCZD9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgs4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- polybasic membrane localization signal
- protein kinase binding
- calmodulin binding
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- GTPase Activating Protein domain
Pathways
Biological processes and signaling networks where the Rgs4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- schizophrenia
- seizures
- atrial fibrillation
- tumorigenesis
- HER2 negative hormone receptor negative breast cancer
- autosomal dominant polycystic kidney disease
- neoplasia
- airway hyperresponsiveness
- Huntington disease
regulates
- AKT
- VEGF
- Ca2+
- p38 MAPK
- NMDA receptor
- cyclic AMP
- ERK
- ERK1/2
- MAPK3
- MAPK
role in cell
- signaling in
- activation in
- expression in
- apoptosis
- proliferation
- phosphorylation in
- invasion
- production in
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgs4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- response to ethanol
- negative regulation of cell growth involved in cardiac muscle cell development
- response to amphetamine
- G-protein coupled receptor signaling pathway
- response to cocaine
- positive regulation of excitatory postsynaptic membrane potential
- regulation of calcium ion transport
- negative regulation of dopamine receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- calmodulin binding
- G-protein alpha-subunit binding
- GTPase activity
- GTPase activator activity