Slc46a1 Gene Summary [Rat]
Predicted to enable folic acid:proton symporter activity; heme transmembrane transporter activity; and methotrexate transmembrane transporter activity. Predicted to be involved in folate import across plasma membrane; monoatomic cation transport; and tetrahydrofolate biosynthetic process. Located in brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc46a1 |
| Official Name | solute carrier family 46 member 1 [Source:RGD Symbol;Acc:1309472] |
| Ensembl ID | ENSRNOG00000010291 |
| Bio databases IDs | |
| Aliases | solute carrier family 46 member 1 |
| Synonyms | 1110002C08Rik, D11Ertd18e, G21, HCP1, hPCFT, HsPCFT, MGC9564, PCFT, RGD1309472, rPCFT, solute carrier family 46 member 1, solute carrier family 46, member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc46a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methotrexate transporter
- hydrogen ion transporter
- Major Facilitator Superfamily
- Multidrug resistance protein
- folate transporter
- heme transporter
- symporter
- solute:hydrogen symporter
- transporter
Pathways
Biological processes and signaling networks where the Slc46a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- hereditary folate malabsorption
- pancytopenia
- infection by vesicular stomatitis virus
- infection by HIV-1
regulated by
- IFNG
- dexamethasone
- poly rI:rC-RNA
- lipopolysaccharide
- Listeria monocytogenes
- Pam3-Cys-Ser-Lys4
- B lymphocytes
- Flagellin
- CpG oligonucleotide
- imiquimod
role in cell
- differentiation
- apoptosis
- homeostasis in
- accumulation
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- endosomes
- granules
- apical membrane
- basolateral membrane
- early endosomes
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc46a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- folic acid transport
- transmembrane transport
- folic acid metabolic process
- methotrexate transport
- heme metabolic process
- heme transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- endosome
- cytoplasm
- endosome membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- folic acid transporter activity
- transmembrane transporter activity
- heme transporter activity
- hydrogen ion transmembrane transporter activity
- methotrexate transporter activity
- symporter activity
- folic acid binding