Epo Gene Summary [Rat]
Predicted to enable erythropoietin receptor binding activity; protein kinase activator activity; and receptor ligand activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of activated T cell proliferation; and response to dexamethasone. Located in cell body and extracellular space. Used to study retinal detachment. Biomarker of cholangiocarcinoma; eye disease (multiple); transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epo |
| Official Name | erythropoietin [Source:RGD Symbol;Acc:2559] |
| Ensembl ID | ENSRNOG00000001412 |
| Bio databases IDs | |
| Aliases | erythropoietin |
| Synonyms | DBAL, ECYT5, EP, epoetin, epoetin alfa, epoetin alfa-epbx, epoetin alfa hexal, epoetin alpha, epoetin α, Epogen, ERYPO, Erythropoietin, erythropoietin alfa, heberitro, HX575, MVCD2, recombinant 1-165 erythropoietin, glycoform alpha, recombinant 1-165 erythropoietin, glycoform α, recombinant erythropoietin-alpha, recombinant erythropoietin-α, r-huEPO, rHuEPO-alpha, rHuEPO-α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- extracellular domain
- erythropoietin receptor binding
- alpha helix
- transmembrane domain
- Erythropoietin/thrombopoietin
- hormone
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Epo gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hepatitis C
- infection
- metastasis
- neoplasia
- anemia
- edema
- acute stroke
- acute myocardial infarction
- sepsis
role in cell
- cell death
- expression in
- quantity
- activation in
- apoptosis
- binding
- damage
- transmembrane potential
- proliferation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- response to estrogen stimulus
- response to salt stress
- positive regulation of cell proliferation
- positive regulation of neuron differentiation
- positive regulation of Ras protein signal transduction
- response to axon injury
- positive regulation of tyrosine phosphorylation of STAT protein
- erythrocyte maturation
- negative regulation of transcription from RNA polymerase II promoter
- response to hypoxia
- positive regulation of transcription, DNA-dependent
- cellular hyperosmotic response
- positive regulation of neuron projection development
- response to testosterone stimulus
- response to electrical stimulus
- signal transduction
- blood circulation
- hemoglobin biosynthetic process
- erythropoietin-mediated signaling pathway
- acute-phase response
- positive regulation of activated T cell proliferation
- embryo implantation
- erythrocyte differentiation
- positive regulation of ERK1 and ERK2 cascade
- negative regulation of cation channel activity
- negative regulation of calcium ion transport into cytosol
- response to interleukin-1
- response to lipopolysaccharide
- response to vitamin A
- response to dexamethasone stimulus
- myeloid cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cell body
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- erythropoietin receptor binding
- protein binding
- protein kinase activator activity
- cytokine activity
- hormone activity