Dzip1 Gene Summary [Rat]
Predicted to enable BBSome binding activity and molecular adaptor activity. Predicted to be involved in several processes, including cilium organization; positive regulation of protein localization to cilium; and protein-containing complex localization to centriolar satellite. Predicted to act upstream of or within several processes, including positive regulation of cilium assembly; protein localization to cilium; and smoothened signaling pathway. Predicted to be located in several cellular components, including ciliary base; microtubule organizing center; and nuclear speck. Predicted to be part of ciliary transition fiber. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in mitral valve prolapse and spermatogenic failure 47. Orthologous to human DZIP1 (DAZ interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dzip1 |
| Official Name | DAZ interacting zinc finger protein 1 [Source:RGD Symbol;Acc:1307701] |
| Ensembl ID | ENSRNOG00000010311 |
| Bio databases IDs | |
| Aliases | DAZ interacting zinc finger protein 1 |
| Synonyms | 2510025K24Rik, 2810422M04RIK, DAZ interacting protein 1, DAZ interacting zinc finger protein 1, DZIP, DZIP2, DZIPt1, LOC102555347, MMVP3, MVP3, SPGF47 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dzip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- binding protein
- protein binding
- Iguana/Dzip1-like DAZ-interacting protein N-terminal
- iSH2_PI3K_IA_R
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 47
- myxomatous mitral valve prolapse type 3
role in cell
- assembly
- organization
- ingression in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- intracellular membrane-bounded organelle
- ciliary transition fiber
- Nucleus
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dzip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- germ cell development
- maintenance of protein location in cell
- heart development
- cytoplasmic sequestering of protein
- cilium morphogenesis
- spermatogenesis
- microtubule basal body organization
- smoothened signaling pathway
- establishment of localization in cell
- positive regulation of flagellum assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- centriole
- cilium basal body
- nuclear speck
- centriolar satellite
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- binding, bridging