DZIP1 Gene Summary [Human]
Predicted to enable metal ion binding activity. Involved in cilium assembly; germ cell development; and spermatogenesis. Located in cytosol; microtubule organizing center; and nucleoplasm. Colocalizes with centriole. Implicated in mitral valve prolapse and spermatogenic failure 47. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DZIP1 |
| Official Name | DAZ interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:20908] |
| Ensembl ID | ENSG00000134874 |
| Bio databases IDs | |
| Aliases | DAZ interacting zinc finger protein 1 |
| Synonyms | 2510025K24Rik, 2810422M04RIK, DAZ interacting protein 1, DAZ interacting zinc finger protein 1, DZIP, DZIP2, DZIPt1, LOC102555347, MMVP3, MVP3, SPGF47 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DZIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- binding protein
- protein binding
- Iguana/Dzip1-like DAZ-interacting protein N-terminal
- iSH2_PI3K_IA_R
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 47
- myxomatous mitral valve prolapse type 3
role in cell
- assembly
- organization
- ingression in
- ciliogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- intracellular membrane-bounded organelle
- ciliary transition fiber
- Nucleus
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DZIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- germ cell development
- maintenance of protein location in cell
- heart development
- cytoplasmic sequestering of protein
- cilium morphogenesis
- spermatogenesis
- microtubule basal body organization
- smoothened signaling pathway
- establishment of localization in cell
- positive regulation of flagellum assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- centriole
- cilium basal body
- nuclear speck
- centriolar satellite
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- binding, bridging