Pcmt1 Gene Summary [Rat]
Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; cellular response to hypoxia; and negative regulation of cardiac muscle cell apoptotic process. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Biomarker of high grade glioma. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcmt1 |
| Official Name | protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 [Source:RGD Symbol;Acc:3268] |
| Ensembl ID | ENSRNOG00000014330 |
| Bio databases IDs | |
| Aliases | protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 |
| Synonyms | AC156391.5, BC020402, PCM, PIMT, protein-L-isoaspartate (D-aspartate) O-methyltransferase, protein-L-isoaspartate (D-aspartate) O-methyltransferase 1, Protein-l-isoaspartate O-methytransferase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcmt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
- precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
- RNA methyltransferase domain
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
- protein-L-isoaspartate(D-aspartate) O-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- metastasis
- liver cancer
- epithelial cancer
- neoplasia
- prostate cancer
- seizures
- growth failure
- hepatocellular carcinoma
- Huntington disease
role in cell
- cellular infiltration by
- invasion by
- apoptosis
- phosphorylation in
- proliferation
- function
- migration
- cell viability
- adhesion
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cytosol
- basolateral membrane
- brush border
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcmt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein repair
- protein methylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- protein-L-isoaspartate (D-aspartate) O-methyltransferase activity