Adprhl2 Gene Summary [Rat]
Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, acting on glycosyl bonds; and magnesium ion binding activity. Predicted to be involved in DNA repair; negative regulation of necroptotic process; and peptidyl-serine ADP-deribosylation. Predicted to act upstream of or within cellular response to superoxide. Predicted to be located in cytoplasm; nuclear body; and site of DNA damage. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in stress-induced childhood-onset neurodegeneration with variable ataxia and seizures. Orthologous to human ADPRS (ADP-ribosylserine hydrolase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adprhl2 |
| Official Name | ADP-ribosylhydrolase like 2 [Source:RGD Symbol;Acc:1309068] |
| Ensembl ID | ENSRNOG00000010849 |
| Bio databases IDs | |
| Aliases | ADP-ribosylhydrolase like 2 |
| Synonyms | ADPRHL2, ADP-ribosylserine hydrolase, ARH3, CONDSIAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adprhl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- poly(ADp-ribose) glycohydrolase
- N-glycosyl glycosylase
- glycosidase
- ADP-ribosylglycohydrolase
- enzyme
- DraG
- protein binding
- deacetylase
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- poly(ADP-ribose)
- DNA polymerase
- AIFM1
- ADP-D-ribose
regulated by
- magnesium
disease
- stress-induced childhood-onset neurodegeneration with variable ataxia and seizures
- ischemic injury
role in cell
- autophagy in
- olaparib sensitivity
- survival
- response by
- accumulation in
- degradation in
- veliparib resistance
- olaparib resistance
- niraparib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adprhl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- cellular response to superoxide
- base-excision repair, gap-filling
- negative regulation of necroptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- protein binding
- poly(ADP-ribose) glycohydrolase activity
- hydrolase activity, hydrolyzing O-glycosyl compounds