Aifm1 Gene Summary [Rat]
Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including cellular response to aldosterone; cellular response to estradiol stimulus; and cellular response to nitric oxide. Predicted to be located in cytosol and mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aifm1 |
| Official Name | apoptosis inducing factor, mitochondria associated 1 [Source:RGD Symbol;Acc:620817] |
| Ensembl ID | ENSRNOG00000006067 |
| Bio databases IDs | |
| Aliases | apoptosis inducing factor, mitochondria associated 1 |
| Synonyms | AIF, apoptosis inducing factor mitochondria associated 1, apoptosis inducing factor, mitochondria associated 1, apoptosis-inducing factor, mitochondrion-associated 1, AUNX1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, Hq, LKMCD, LOC103694586, NADMR, NAMSD, PDCD8, SEMDHL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aifm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- NADH or NADPH oxidoreductase
- mitochondrial presequence
- DNA binding domain
- electron-transferring-flavoprotein dehydrogenase
- nuclear localization sequence
- enzyme
- protein binding
- cleavage site
- DNA binding
- FAD binding
- binding protein
- Pyridine nucleotide-disulphide oxidoreductase
- NADPH oxidase
- Apoptosis-inducing factor, mitochondrion-associated, C-term
Pathways
Biological processes and signaling networks where the Aifm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- Parkinson disease
- Alzheimer disease
- auditory neuropathy
- combined oxidative phosphorylation deficiency 6
- X-linked deafness type 5
- stroke
- hypomyelinating leukodystrophy and spondylometaphyseal dysplasia
- lactic acidemia
- leukodystrophy
role in cell
- expression in
- senescence
- function in
- phosphorylation in
- apoptosis
- proliferation
- autophagy in
- destabilization in
- quantity
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- mitochondrial fraction
- pH resistant lipid raft fraction
- perinuclear region
- inner membrane
- Nucleus
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- photoreceptor inner segments
- mitoplasts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aifm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome condensation
- response to toxin
- positive regulation of neuron apoptotic process
- positive regulation of necroptosis
- protein import into mitochondrial intermembrane space
- cellular response to estradiol stimulus
- response to ischemia
- positive regulation of apoptotic process
- apoptotic process
- cellular response to nitric oxide
- cellular response to hydrogen peroxide
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- cellular response to hypoxia
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- mitochondrial respiratory chain complex assembly
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytosol
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- FAD binding
- DNA binding
- protein binding
- NADH dehydrogenase activity
- NAD(P)H oxidase activity
- protein dimerization activity
- oxidoreductase activity, acting on NADH or NADPH