Neurod4 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in positive regulation of cell differentiation and retina development in camera-type eye. Predicted to be active in nucleus. Orthologous to human NEUROD4 (neuronal differentiation 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neurod4 |
| Official Name | neuronal differentiation 4 [Source:RGD Symbol;Acc:1310434] |
| Ensembl ID | ENSRNOG00000008449 |
| Bio databases IDs | |
| Aliases | neuronal differentiation 4 |
| Synonyms | ATH-3, Atoh3, bHLHa4, MATH-3, neurogenic differentiation 4, neuronal differentiation 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neurod4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuronal helix-loop-helix transcription factor
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- spontaneous preterm birth
- ataxia
role in cell
- proliferation
- apoptosis
- quantity
- formation
- migration
- commitment
- number
- differentiation
- migration by
- loss
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neurod4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- amacrine cell differentiation
- neuroblast proliferation
- Notch signaling pathway
- cell fate commitment
- camera-type eye development
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity