Tprn Gene Summary [Rat]
Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in auditory receptor cell stereocilium organization; sensory perception of sound; and stereocilium maintenance. Predicted to be located in several cellular components, including microvillus; nucleoplasm; and stereocilium. Predicted to be active in stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 79. Orthologous to human TPRN (taperin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tprn |
| Official Name | taperin [Source:RGD Symbol;Acc:1562935] |
| Ensembl ID | ENSRNOG00000010896 |
| Bio databases IDs | |
| Aliases | taperin |
| Synonyms | C430004E15Rik, C9orf75, DFNB79, FLJ90254, taperin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tprn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 binding
- type 1 serine/threonine specific protein phosphatase inhibitor
- Phostensin PP1-binding and SH3-binding region
- actin binding
- protein phosphatase binding
- PP1-regulatory protein, Phostensin N-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ear malformation
- autosomal recessive deafness type 79
- familial nonsyndromic hearing impairment
- colon carcinoma
- colon epithelial cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- autosomal recessive deafness
regulated by
role in cell
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- stereocilia
- nucleoplasm
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tprn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- sensory perception of sound
Cellular Component
Where in the cell the gene product is active
- microvillus
- cytoplasm
- stereocilium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding
- actin binding
- protein phosphatase 1 binding