Myo1c Gene Summary [Rat]
Enables actin filament binding activity; calmodulin binding activity; and microfilament motor activity. Involved in positive regulation of actin filament polymerization and positive regulation of cellular response to insulin stimulus. Located in membrane raft; ruffle membrane; and stereocilium bundle. Orthologous to human MYO1C (myosin IC). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo1c |
| Official Name | myosin 1C [Source:RGD Symbol;Acc:620443] |
| Ensembl ID | ENSRNOG00000004072 |
| Bio databases IDs | |
| Aliases | myosin 1C |
| Synonyms | LOC100365624, LOC686250, mm1beta, MMIb, MMI-beta, MMI-β, MYO1E, MyoIC, myosin 1C, myosin IC, Myosin I Heavy Chain, MYR2, Nm1, NMI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myo1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- calmodulin binding
- Myosin and Kinesin motor domain
- enzyme binding
- microfilament motor protein
- enzyme
- protein binding
- receptor binding
- motor domain
- Myosin head (motor domain)
- actin filament binding
- Calmodulin-binding motif
- IQ domain
- Unconventional myosin tail, actin- and lipid-binding
- Myosin
- cargo binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neoplasia
- Alzheimer disease
- familial nonsyndromic hearing impairment
- pancreatic epithelial cancer
- heart failure
- idiopathic pulmonary fibrosis
- rheumatoid arthritis
- complete testicular feminization syndrome
- ductal pancreatic cancer
role in cell
- expression in
- proliferation
- migration
- molecular cleavage in
- localization
- ruffling
- development
- assembly
- redistribution
- dynamics
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- caveolae-derived endocytic vesicles
- cytoplasmic vesicle membrane
- cellular membrane
- Nucleus
- Plasma Membrane
- actin filaments
- lipid droplets
- cytosol
- cortical cytoplasm
- stereocilia
- membrane ruffles
- basal membrane
- lateral plasma membrane
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- neurites
- membrane rafts
- detergent insoluble microdomains
- brush border
- microvilli
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myo1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- vesicle transport along actin filament
- positive regulation of cellular response to insulin stimulus
- vascular endothelial growth factor signaling pathway
- actin filament organization
- cellular response to interferon-gamma
- regulation of tight junction assembly
- endocytosis
- actin filament-based movement
- protein targeting to membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- nuclear body
- phagocytic vesicle
- nucleolus
- plasma membrane
- nucleoplasm
- cytoplasmic vesicle membrane
- basal plasma membrane
- extracellular vesicular exosome
- brush border
- microvillus
- cytoplasm
- cell cortex
- stress fiber
- membrane raft
- membrane
- actin cytoskeleton
- unconventional myosin complex
- ruffle membrane
- cytosol
- stereocilium membrane
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- small GTPase binding
- receptor binding
- microfilament motor activity