Myh9 Gene Summary [Rat]
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | Myh9 |
| Official Name | myosin, heavy chain 9 [Source:RGD Symbol;Acc:3140] |
| Ensembl ID | ENSRNOG00000004860 |
| Bio databases IDs | |
| Aliases | myosin, heavy chain 9 |
| Synonyms | BDPLT6, DFNA17, EPSTS, FLTN, FTNS, MATINS, MHA, MIIA, MNMM IIA, Myh9l1, Myhn-1, Myosib IIA, MYOSIN HEAVY CHAIN 9, myosin, heavy chain 9, myosin, heavy polypeptide 9, non-muscle, Myosin IIA, Myosin IIA Heavy Chain, NM2A, NMHC-II-A, NM-IIA, NMMHC-A, NMMHC-IIA, NONMUSCLE MYOSIN2 HEAVY CHAIN type A, TU72.6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Myh9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- protein binding activity, bridging
- helix-rich Mycoplasma protein
- identical protein binding
- globular head domain
- head domain
- Putative golgin subfamily A member 2-like protein 5
- Tropomyosin
- actin binding
- tail domain
- rod domain
- Acidic casein kinase ii consensus phosphorylation site
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- protein kinase binding
- PspA/IM30 family
- Myosin and Kinesin motor domain
- Myosin tail
- protein binding
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RIM-binding protein of the cytomatrix active zone
- integrin binding
- protein homodimerization
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
- viral receptor
- ADP binding
- Synaptonemal complex protein 1 (SCP-1)
- G-protein-coupled receptor binding
- ATP binding
- microfilament motor protein
- Myosin N-terminal SH3-like domain
- coiled-coil domain
- enzyme
- Golgin subfamily A member 5
- chromosome segregation protein SMC, common bacterial type
- HOOK protein coiled-coil region
- Cortexillin I, coiled coil
- Hyaluronan mediated motility receptor N-terminal
- rad50
- Na+/K+-exchanging ATPase
- protein domain specific binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- actin filament binding
- RecF/RecN/SMC N terminal domain
- Domain of unknown function (DUF4686)
- Apolipoprotein A1/A4/E domain
Pathways
Biological processes and signaling networks where the Myh9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- chronic obstructive pulmonary disease
- benign neoplasia
- Sebastian syndrome
- macrothrombocytopenia and granulocyte inclusions
- hearing loss
- obesity
- diabetic nephropathy
- glioma
role in cell
- production in
- aggregation
- expression in
- growth
- proliferation
- migration
- phosphorylation in
- differentiation
- quantity
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cortical cytoskeleton
- ruffle
- exocytic vesicle
- spindle apparatus
- extracellular vesicles
- transverse arc
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- peripheral lamellae
- membrane surface
- cellular membrane
- actin ring
- focal adhesions
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- contractile rings
- actin filaments
- midbody
- immunological synapses
- cell-cell contacts
- cytosol
- cytoplasmic face of plasma membrane
- proplatelets
- apical membrane
- uropod
- lateral plasma membrane
- nuclear bodies
- spindle pole
- cortical granules
- neuromuscular junctions
- growth cone
- myosin filaments
- actin stress fibers
- zonula adherens
- membrane rafts
- brush border
- cleavage furrow
- cellular protrusions
- cell membrane leading edge
- perikaryon
- exosomes
- phagosomes
- cell-cell adherens junctions
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Myh9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- protein transport
- meiotic spindle organization
- cytokinetic process
- integrin-mediated signaling pathway
- phagocytosis, engulfment
- angiogenesis
- in utero embryonic development
- establishment of T cell polarity
- regulated secretory pathway
- platelet formation
- actin filament-based movement
- monocyte differentiation
- platelet aggregation
- actomyosin structure organization
- cortical granule exocytosis
- myoblast fusion
- blood vessel endothelial cell migration
- lysosome localization
- membrane protein ectodomain proteolysis
- plasma membrane repair
- establishment of meiotic spindle localization
- endodermal cell differentiation
- uropod organization
- leukocyte migration
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cleavage furrow
- internal side of plasma membrane
- immunological synapse
- extracellular vesicular exosome
- brush border
- focal adhesion
- actomyosin contractile ring
- stress fiber
- actin cytoskeleton
- ruffle
- myosin filament
- cytosol
- neuromuscular junction
- signalosome
- cortical granule
- cell leading edge
- actomyosin
- plasma membrane
- nucleus
- adherens junction
- uropod
- cytoplasm
- membrane
- myosin II complex
- spindle
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- protein homodimerization activity
- integrin binding
- ADP binding
- microfilament motor activity
- motor activity
- actin filament binding
- ATP binding
- calmodulin binding
- RNA binding
- protein binding
- actin binding
- cadherin binding
- protein anchor