Cyp2u1 Gene Summary [Rat]
Predicted to enable arachidonate omega-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in omega-hydroxylase P450 pathway and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 56. Orthologous to human CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp2u1 |
| Official Name | cytochrome P450, family 2, subfamily u, polypeptide 1 [Source:RGD Symbol;Acc:1309433] |
| Ensembl ID | ENSRNOG00000011053 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 2, subfamily u, polypeptide 1 |
| Synonyms | 8430436A10Rik, cytochrome P450 family 2 subfamily U member 1, cytochrome P450, family 2, subfamily u, polypeptide 1, P450TEC, SPG49, SPG56 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp2u1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- unspecific monooxygenase
- monooxygenase
- enzyme
Pathways
Biological processes and signaling networks where the Cyp2u1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dystrophy
- autosomal recessive spastic paraplegia type 56
- spastic paraplegia
- hereditary disorder
- hereditary spastic paraplegia
- autosomal recessive spastic paraplegia type 56 with pseudoxanthoma elasticum
- short-term memory impairment
regulated by
- beta-naphthoflavone
- valproic acid
- tretinoin
- TCOF1
- GABA
regulates
- arachidonic acid
- 19-hydroxyeicosatetraenoic acid
- ubiquinol 9
- docosahexaenoic acid
- succinic acid
- ubiquinol-10
- cytochrome
- ubiquinone 9
- NADH
- 20-hydroxyeicosatetraenoic acid
role in cell
- accumulation
- replication in
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyp2u1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organic acid metabolic process
- omega-hydroxylase P450 pathway
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- iron ion binding
- steroid hydroxylase activity
- arachidonic acid omega-hydroxylase activity
- monooxygenase activity
- heme binding