Tcof1 Gene Summary [Rat]
Predicted to enable protein heterodimerization activity; protein-macromolecule adaptor activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcof1 |
| Official Name | treacle ribosome biogenesis factor 1 [Source:RGD Symbol;Acc:1309850] |
| Ensembl ID | ENSRNOG00000026108 |
| Bio databases IDs | |
| Aliases | treacle ribosome biogenesis factor 1 |
| Synonyms | MFD1, TCS, TCS1, treacle, treacle ribosome biogenesis factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tcof1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding activity, bridging
- Treacher Collins syndrome protein Treacle
- protein binding
- LisH
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- Treacher-Collins syndrome type 1
- exencephaly
- hypoplasia
- postmenopausal osteoporosis
- anophthalmia
- hereditary disorder
- Treacher Collins-Franceschetti syndrome
- microcephaly
role in cell
- migration
- expression in
- phosphorylation in
- formation
- apoptosis
- proliferation
- number
- development
- quantity
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pseudo nucleolar organizer
- fibrillar center
- cytosol
- dense fibrillar component
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tcof1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- skeletal system development
- neural crest cell development
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter
- neural crest formation
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleolus
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- RNA binding
- protein heterodimerization activity
- protein binding, bridging