Bicra Gene Summary [Rat]
Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 12. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bicra |
| Official Name | BRD4 interacting chromatin remodeling complex associated protein [Source:RGD Symbol;Acc:1306385] |
| Ensembl ID | ENSRNOG00000011262 |
| Bio databases IDs | |
| Aliases | BRD4 interacting chromatin remodeling complex associated protein |
| Synonyms | BRD4 interacting chromatin remodeling complex associated protein, CSS12, GLTSCR1, SMARCK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bicra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Conserved region of unknown function on GLTSCR protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- atrial fibrillation
- male pattern hair loss
- Coffin-Siris syndrome type 12
- late-onset Alzheimer disease
- age-related nuclear cataract disorder
- mental retardation
- right colon cancer
role in cell
- proliferation
- expression in
- upregulation in
- transactivation in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bicra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding