Arid1b Gene Summary [Rat]
Predicted to enable DNA binding activity. Predicted to contribute to nucleosome binding activity. Involved in cellular response to angiotensin and response to ischemia. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of SWI/SNF complex and nBAF complex. Predicted to be active in nucleoplasm. Used to study ischemia. Biomarker of hypertension and ischemia. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome; Coffin-Siris syndrome 1; intellectual disability; lung non-small cell carcinoma; and neuroblastoma. Orthologous to human ARID1B (AT-rich interaction domain 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid1b |
| Official Name | AT-rich interaction domain 1B [Source:RGD Symbol;Acc:708504] |
| Ensembl ID | ENSRNOG00000017030 |
| Bio databases IDs | |
| Aliases | AT-rich interaction domain 1B |
| Synonyms | 6A3-5, 8030481M12, 9330189K18RIK, Ardi1b, AT-rich interaction domain 1B, B230217J03RIK, BAF210, BAF250B, BRIGHT, CSS1, DAN15, Eld/Osa, ELD/OSA1, LOC497729, mKIAA1235, MRD12, OSA2, P250R, SMARCF2, SMCF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arid1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Eld/osa homology domain
- protein binding
- ARID/BRIGHT DNA binding domain
- transcription factor activity
- DNA binding
- SWI/SNF-like complex subunit BAF250/Osa
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- breast carcinoma
- autosomal dominant mental retardation type 12
- liver cancer
- medulloblastoma WNT-subtype
- brain cancer
- metastasis
- COVID-19
- hereditary disorder
- renal clear cell adenocarcinoma
role in cell
- expression in
- proliferation
- survival
- length
- number
- arborization
- arborization in
- accumulation in
- outgrowth
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arid1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- positive regulation of gene expression, epigenetic
- nervous system development
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- response to ischemia
- positive regulation of transcription, DNA-dependent
- positive regulation of T cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
Cellular Component
Where in the cell the gene product is active
- SWI/SNF complex
- npBAF complex
- cytosol
- brahma complex
- nBAF complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- nucleosome binding