Tmem63c Gene Summary [Rat]
Predicted to enable calcium-activated cation channel activity and osmolarity-sensing monoatomic cation channel activity. Involved in glomerular filtration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87. Orthologous to human TMEM63C (transmembrane protein 63C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem63c |
| Official Name | transmembrane protein 63c [Source:RGD Symbol;Acc:1310207] |
| Ensembl ID | ENSRNOG00000011334 |
| Bio databases IDs | |
| Aliases | transmembrane protein 63c |
| Synonyms | 4932420N09, 9330187M14RIK, C14orf171, CSC1, hsCSC1, RGD1310207, SPG87, transmembrane protein 63C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmem63c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- osmosensor
- calcium activated cation channel
- Calcium-dependent channel, 7TM region, putative phosphate
- channel/pore class transporter
- Late exocytosis, associated with Golgi transport
- inorganic uptake permease
- Cytosolic domain of 10TM putative phosphate transporter
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmem63c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- glomerular filtration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity