Nppa Gene Summary [Rat]
Enables hormone activity. Involved in several processes, including cGMP biosynthetic process; cellular response to mechanical stimulus; and regulation of monoatomic cation transmembrane transport. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in brush border; mast cell granule; and perinuclear region of cytoplasm. Is active in glycinergic synapse. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nppa |
| Official Name | natriuretic peptide A [Source:RGD Symbol;Acc:3193] |
| Ensembl ID | ENSRNOG00000008176 |
| Bio databases IDs | |
| Aliases | natriuretic peptide A |
| Synonyms | ANF, ANP, ATFB6, Atrial natriuretic factor, Atrial Natriuretic Peptide Prohormone, ATRST2, CDD, CDD-ANF, natriuretic peptide A, natriuretic peptide type A, PND, Prepronatriodilatin, RATANF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nppa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Atrial natriuretic peptide
- G-protein-coupled receptor binding
- hormone
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Nppa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myocardial infarction
- septic shock
- hyperthyroidism
- hypertension
- salt-sensitive essential hypertension
- interstitial fibrosis
- renal failure
- ventricular tachycardia
- dilated cardiomyopathy
- aortic stenosis
role in cell
- apoptosis
- activation in
- production in
- phosphorylation in
- activation
- proliferation
- growth
- synthesis in
- expression in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- Plasma Membrane
- lysosome
- Golgi Apparatus
- granules
- neurites
- synapse
- dense-core vesicles
- secretory vesicles
- secretory granules
- brush border
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nppa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- cGMP-mediated signaling
- cGMP biosynthetic process
- positive regulation of cardiac muscle contraction
- aortic valve morphogenesis
- negative regulation of JUN kinase activity
- regulation of atrial cardiomyocyte membrane repolarization
- cardiac conduction system development
- receptor guanylyl cyclase signaling pathway
- negative regulation of systemic arterial blood pressure
- female pregnancy
- vasodilation
- protein folding
- regulation of blood pressure
- neuropeptide signaling pathway
- response to muscle stretch
- cardiac muscle hypertrophy in response to stress
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- macromolecular complex
- perikaryon
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- hormone activity
- receptor binding
- hormone receptor binding
- neuropeptide receptor binding