Chkb Gene Summary [Rat]
Enables choline kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within muscle organ development and phosphatidylcholine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chkb |
| Official Name | choline kinase beta [Source:RGD Symbol;Acc:61826] |
| Ensembl ID | ENSRNOG00000011404 |
| Bio databases IDs | |
| Aliases | choline kinase beta |
| Synonyms | CHETK, CHKL, choline kinase beta, choline kinase β, CK, CKB, Ck/Ek, CKEKB, Ck/Ek-beta, Ck/Ek-β, EK, EKB, MDCMC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Protein Kinases, catalytic domain
- Phosphotransferase enzyme family
- ethanolamine kinase
- choline kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myopia
- megaconial type congenital muscular dystrophy
- muscular dystrophy
- HER2 negative hormone receptor negative breast cancer
- hereditary disorder
- cardiac hypertrophy
- localized cutaneous leishmaniasis
- arrhythmia
- rostrocaudal muscular dystrophy
role in cell
- expression in
- phosphorylation in
- quantity
- activity
- beta-oxidation in
- ploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chkb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- phosphatidylethanolamine biosynthetic process
- CDP-choline pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ethanolamine kinase activity
- choline kinase activity