Cdkn3 Gene Summary [Rat]
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn3 |
| Official Name | cyclin-dependent kinase inhibitor 3 [Source:RGD Symbol;Acc:1307781] |
| Ensembl ID | ENSRNOG00000009785 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 3 |
| Synonyms | 2410006H10Rik, CDI1, CDK2-associated dual specificity phosphatase, CIP2, CYCLIN-DEPENDENT KINASE-ASSOCIATED protein PHOSPHATASE, Cyclin Dependent Kinase Inhibitor 3, KAP, KAP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdkn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Cdkn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- hepatocellular carcinoma
- colon cancer
- liver cancer
- epithelial cancer
- astrocytoma
- glioma formation
- non-small cell lung carcinoma
- non-small cell lung cancer
- dental caries
role in cell
- expression in
- phosphorylation in
- apoptosis
- proliferation
- migration
- mitosis
- invasion
- DNA damage response
- G1/S phase transition
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intranucleolar focus
- perinuclear region
- Nucleus
- centrosome
- cytosol
- nucleoli
- central spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdkn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- G1/S transition of mitotic cell cycle
- regulation of cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity