Mtmr9 Gene Summary [Rat]
Predicted to enable enzyme regulator activity and protein phosphatase binding activity. Predicted to be involved in negative regulation of autophagy; protein stabilization; and regulation of dephosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtmr9 |
| Official Name | myotubularin related protein 9 [Source:RGD Symbol;Acc:628840] |
| Ensembl ID | ENSRNOG00000011560 |
| Bio databases IDs | |
| Aliases | myotubularin related protein 9 |
| Synonyms | 9430075G12Rik, AA516943, AC270277.2, C8orf9, LIP-STYX, mMTMH3, MTMR8, myotubularin related protein 9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtmr9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SET binding domain
- protein phosphatase binding
- phosphatase
- Myotubularin-like phosphatase domain
- coiled-coil domain
- protein binding
- enzyme regulator activity
- Pleckstrin homology-like domain
- PTP_DSP_cys
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- essential hypertension
- prostatic carcinoma
- schizophrenia
- neuroticism
regulated by
- MTMR6
- thioguanine nucleotide
regulates
- phosphatidylinositol
- phosphatidylinositol 4,5-bisphosphate
- MTMR6
- phosphatidylinositol 3,4-bisphosphate
- phosphtidylinositol 5-phosphate
- phosphatidylinositol 4-phosphate
- phosphatidylinositol-3,4,5-triphosphate
- phosphatidylinositol-3-phosphate
- phosphatidylinositol 3,5-bisphosphate
- inositol 1,3-bisphosphate
role in cell
- apoptosis
- stabilization in
- growth
- autophagy by
- growth in
- capivasertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- cytoplasmic particles
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtmr9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phosphatase activity
- negative regulation of autophagy
- protein stabilization
- endocytosis
- phosphatidylinositol dephosphorylation
- regulation of phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- ruffle membrane
- endoplasmic reticulum
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- enzyme regulator activity