Aktip Gene Summary [Rat]
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein K63-linked ubiquitination; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in nucleus. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aktip |
| Official Name | AKT interacting protein [Source:RGD Symbol;Acc:1311170] |
| Ensembl ID | ENSRNOG00000011956 |
| Bio databases IDs | |
| Aliases | AKT interacting protein |
| Synonyms | AKT interacting protein, AL023020, Fif, Ft, FT1, FTS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aktip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- UBCc_UEV
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cardiac fibrosis
- cardiac hypertrophy
role in cell
- apoptosis
- organization
- generation
- transport
- expansion
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aktip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- positive regulation of protein binding
- endosome organization
- apoptotic process
- protein transport
- positive regulation of protein phosphorylation
- early endosome to late endosome transport
- protein neddylation
- endosome to lysosome transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- FHF complex
- HOPS complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- NEDD8 ligase activity
- small conjugating protein ligase activity