Bmp6 Gene Summary [Rat]
Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in extracellular space and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp6 |
| Official Name | bone morphogenetic protein 6 [Source:RGD Symbol;Acc:2214] |
| Ensembl ID | ENSRNOG00000013717 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 6 |
| Synonyms | bone morphogenetic protein 6, D13Wsu115e, IO, VGR, VGR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- growth factor
- TGF-beta propeptide
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Bmp6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- HIF1α Signaling
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- preeclampsia
- colorectal cancer
- chronic obstructive pulmonary disease
- reperfusion injury
- epithelial neoplasia
- abdominal cancer
- cancer
- epithelial cancer
- organismal death
role in cell
- expression in
- production in
- apoptosis
- cell viability
- phosphorylation in
- recruitment in
- growth
- migration
- proliferation
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- positive regulation of cell proliferation
- positive regulation of neuron differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of endothelial cell differentiation
- cellular response to iron ion
- bone development
- cellular iron ion homeostasis
- negative regulation of transcription from RNA polymerase II promoter
- response to retinoic acid
- inflammatory response
- skeletal system development
- immune response
- kidney development
- cellular response to BMP stimulus
- BMP signaling pathway
- response to glucocorticoid stimulus
- osteoblast differentiation
- response to magnesium ion
- positive regulation of protein secretion
- positive regulation of SMAD protein import into nucleus
- positive regulation of epithelial cell proliferation
- positive regulation of aldosterone biosynthetic process
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of bone mineralization
- neuron differentiation
- positive regulation of vascular permeability
- type B pancreatic cell development
- cellular response to mechanical stimulus
- eye development
- male genitalia development
- positive regulation of gene expression
- endochondral ossification
- positive regulation of endothelial cell proliferation
- positive regulation of chondrocyte differentiation
- response to activity
- positive regulation of lipopolysaccharide-mediated signaling pathway
- positive regulation of aldosterone secretion
- cartilage development
- negative regulation of cell-cell adhesion mediated by cadherin
Cellular Component
Where in the cell the gene product is active
- extracellular space
- vesicle
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- protein heterodimerization activity
- cytokine activity
- BMP receptor binding