Mfsd8 Gene Summary [Rat]
Predicted to enable chloride channel activity; fluoride channel activity; and iodide transmembrane transporter activity. Predicted to be involved in autophagosome maturation and lysosome organization. Predicted to act upstream of or within several processes, including TORC1 signaling; neurogenesis; and regulation of catabolic process. Predicted to be located in endosome membrane and lysosome. Predicted to be active in lysosomal membrane and mitochondrion. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mfsd8 |
| Official Name | major facilitator superfamily domain containing 8 [Source:RGD Symbol;Acc:1310132] |
| Ensembl ID | ENSRNOG00000012729 |
| Bio databases IDs | |
| Aliases | major facilitator superfamily domain containing 8 |
| Synonyms | 2810423E13Rik, Ab2-276, AC160757.2, CCMD, CLN7, major facilitator superfamily domain containing 8, RGD1310132 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mfsd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- anion channel
- chloride channel
- Major Facilitator Superfamily
- inorganic anion transporter
- ion channel
- iodide transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neuronal ceroid lipofuscinosis
- macular dystrophy with central cone involvement
- neuronal ceroid lipofuscinosis 7
- retinal dystrophy
- cerebellar ataxia
- hereditary disorder
- late-infantile neuronal ceroid lipofuscinosis
- optic atrophy
- hyperactive behavior
- retinitis pigmentosa
regulated by
role in cell
- apoptosis
- accumulation in
- swelling
- fusion
- differentiation
- development
- autophagy in
- accumulation
- function
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- lysosome
- Mitochondria
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mfsd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- regulation of autophagy
- iodide transport
- neuron development
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- endosome membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- iodide transmembrane transporter activity
- chloride channel activity