Wbp2 Gene Summary [Rat]
Predicted to enable DNA binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to estrogen stimulus; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of macromolecule biosynthetic process. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 107. Orthologous to human WBP2 (WW domain binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wbp2 |
| Official Name | WW domain binding protein 2 [Source:RGD Symbol;Acc:620032] |
| Ensembl ID | ENSRNOG00000007971 |
| Bio databases IDs | |
| Aliases | WW domain binding protein 2 |
| Synonyms | DFNB107, FLJ46550, GRAMD6, WW domain binding protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- PPXY motif
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- Pleckstrin homology-like domain
- estrogen receptor binding
- sequence-specific DNA binding
- proline tyrosine motif
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- Turner syndrome
- autosomal recessive deafness type 107
- autosomal recessive nonsyndromic postlingual hearing loss
- neoplastic cell transformation
- ductal in situ breast cancer
- invasive ductal breast cancer
- nonobstructive azoospermia
- Klinefelter syndrome
role in cell
- expression in
- migration
- phosphorylation in
- proliferation
- invasion by
- growth
- signaling in
- cell-cell adhesion by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- response to estrogen stimulus
- positive regulation of transcription, DNA-dependent
- response to progesterone stimulus
- progesterone receptor signaling pathway
- positive regulation of intracellular estrogen receptor signaling pathway
- establishment of protein localization to chromatin
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to estrogen stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein binding
- transcription coactivator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- estrogen receptor binding