Grhpr Gene Summary [Rat]
Enables adenyl nucleotide binding activity; carboxylic acid binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in dicarboxylic acid metabolic process. Predicted to be located in mitochondrion. Predicted to be part of catalytic complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grhpr |
| Official Name | glyoxylate and hydroxypyruvate reductase [Source:RGD Symbol;Acc:1308851] |
| Ensembl ID | ENSRNOG00000012794 |
| Bio databases IDs | |
| Aliases | glyoxylate and hydroxypyruvate reductase |
| Synonyms | 1110059D05Rik, 6430629L09Rik, GLXR, GLYD, glyoxylate and hydroxypyruvate reductase, glyoxylate reductase/hydroxypyruvate reductase, Hydroxypyruvate/Glyoxylate Reductase, LOC683694, PH2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grhpr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glyoxylate reductase (NADP)
- Rossmann-fold NAD(P)(+)-binding proteins
- hydroxypyruvate reductase
- enzyme
- protein binding
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- glycerate dehydrogenase
- NAD or NADH binding
- NADPH binding
- binding protein
- NADP binding
- protein homodimerization
- glyoxylate reductase
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- cervical cancer
- postmenopausal osteoporosis
- primary hyperoxaluria type II
- major depression
- chronic kidney disease
- non-small cell lung cancer
- epithelial cancer
- liver cancer
- renal clear cell adenocarcinoma
role in cell
- expression in
- ubiquitination in
- epithelial-mesenchymal transition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Grhpr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dicarboxylic acid metabolic process
- glyoxylate metabolic process
- carboxylic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- carboxylic acid binding
- protein binding
- protein homodimerization activity
- NAD binding
- hydroxypyruvate reductase activity
- NADPH binding
- glycerate dehydrogenase activity
- glyoxylate reductase (NADP) activity