Kat6b Gene Summary [Rat]
Predicted to enable chromatin binding activity; histone H3K14 acetyltransferase activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kat6b |
| Official Name | lysine acetyltransferase 6B [Source:RGD Symbol;Acc:1566399] |
| Ensembl ID | ENSRNOG00000012850 |
| Bio databases IDs | |
| Aliases | lysine acetyltransferase 6B |
| Synonyms | B130044K16Rik, GTPTS, HISTONE 4 ACETYLTRANSFERASE, K(lysine) acetyltransferase 6B, lysine acetyltransferase 6B, mKIAA0383, MORF, MOZ2, MYST-4, qkf, querkopf, RGD1566399, ZC2HC6B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kat6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone acetyltransferase
- transcription co-activator
- H15
- NAT_SF
- MOZ/SAS family
- methionine-rich domain
- enzyme
- protein binding
- N-acetyltransferase
- binding protein
- PHD finger superfamily
- Serine and Methionine rich domain
- MYST family zinc finger domain
Pathways
Biological processes and signaling networks where the Kat6b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Say-Barber-Biesecker-Young-Simpson syndrome
- KAT6B-related disorder
- genitopatellar syndrome
- hereditary disorder
- neurodevelopmental disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- mental retardation
- KBG syndrome
regulated by
- beta-estradiol
- cisplatin
- histone H3
- PF-07248144
- BRD2
- AGO1
- rebemadlin
regulates
- DNA endogenous promoter
- RNA polymerase II
- luciferase reporter gene
- DNA promoter
- SMARCA2
role in cell
- quantity
- growth
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kat6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- MOZ/MORF histone acetyltransferase complex
- nucleosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- DNA binding
- H3 histone acetyltransferase activity
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- metal ion binding
- chromatin binding