Tti1 Gene Summary [Rat]
Predicted to be involved in positive regulation of DNA damage checkpoint and regulation of TOR signaling. Predicted to be part of TORC1 complex; TORC2 complex; and TTT Hsp90 cochaperone complex. Predicted to be active in cytoplasm. Orthologous to human TTI1 (TELO2 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tti1 |
| Official Name | TELO2 interacting protein 1 [Source:RGD Symbol;Acc:1562582] |
| Ensembl ID | ENSRNOG00000012880 |
| Bio databases IDs | |
| Aliases | TELO2 interacting protein 1 |
| Synonyms | 2610036D13Rik, KIAA0406, NEDMIM, RGD1562582, smg-10, TELO2 interacting protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tti1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- central domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly and movement abnormalities
- breast cancer
role in cell
- binding in
- stabilization in
- G2/M phase
- dimerization in
- S phase checkpoint control
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tti1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA damage checkpoint
- protein stabilization
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- TORC2 complex
- cytoplasm
- TORC1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding